State drug charges are prosecuted under Rhode Island law in Rhode Island District or Superior Court. Federal drug charges are prosecuted under federal law in U.S. District Court at the John O. Pastore Federal Building in Providence. Federal cases typically involve larger quantities, cross-state operations, federal agency investigations (DEA, FBI), or activity on federal property. Federal sentences are generally longer, often carry mandatory minimums, and follow the Federal Sentencing Guidelines. A Rhode Island state arrest can become a federal case if the U.S. Attorney's office takes jurisdiction, particularly for trafficking quantities or cases tied to ongoing federal investigations.